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MacGyver and Pete have a surprise party planned for a colleague, but when the colleague doesn't show up, MacGyver goes looking for him, and finds him on the verge of committing suicide. When questioned why he would do such a thing, Kelly explains that a con artist has swindled him out of his life savings. MacGyver tells Pete about Kelly's situation and the two of them decide that they will get Kelly's money back from the con

Mac inadvertently leads a hit man to his target, believing that he's helping a father find his lost son.

MacGyver and Pete are testing a new security system at the Strategic Research Development Administration. MacGyver successfully bypasses the security and meets Dr. Jill Ludlam, the system's designer. She tries to turn off the security system, but it doesn't realize that it was just a test. MacGyver and Dr. Ludlam are then forced to find a way out, as the security system, named Sandy, tries to destroy the "intruders."

Posing as a watchmaker who manufactures bomb timers, MacGyver manages to catch a master killer—Piedra—before he attempts an assassination on a high-profile target. However, Piedra isn't about to be stopped for long.

Pete Thornton investigates the supposed death of an old friend, a prominent Russian dissident, and finds he must get his friend's daughter Maria out of the country before the secret police arrest her for an alleged conspiracy. However, while in Russia, Pete bumps into MacGyver, who followed him from the United States. While disappointed MacGyver followed him, Pete gladly welcomes MacGyver into his plans when the secret police arrive to take Maria into custody. Following a high speed boat chase to escape the police, Pete and MacGyver find out from Maria that her father is not dead, he is being held in a maximum security ward at a state mental institution. To get into the mental hospital, MacGyver plays the part of a mad patient and Pete plays the part of a doctor who has been assigned to him. With the help of the other patients, MacGyver is able to escape into Ward Zero, where Pete's friend is held. MacGyver breaks him out and hides him with the other patients

When a mother superior at a religious mission in North Africa asks MacGyver to help a young woman with something, he is glad to help. However, when he finds out the young woman wants him to break her brother out of jail, he may have taken on more than he expected.

At the beginning of the episode, MacGyver literally has to jump onto a moving train that he missed earlier to return top-secret files and documents to the U.S. Government. Soon after, a local tribe stops the train. They take all passengers hostage until the men responsible for the death of the tribal leader's son is found among the passengers.

A 15-year-old genius accidentally hacks into a defective missile guidance system and attracts the attention of both the FBI and some black marketers, who think that she may fix it for them. It's up to MacGyver to save her from being kidnapped by either side.

In Afghanistan, wounded and hunted by the Soviets, MacGyver is given refuge by an Afghan woman and her son. But they are themselves at the mercy of an Afghan thug, who will kill MacGyver if he finds him at his woman.

MacGyver is on his way out of Bulgaria with a secret microfilm, when he meets Penny Parker, a beautiful, talkative American, who is on the run from her lover, a man named Stephan Frolov. She stashes some jewels on MacGyver, thus making him a suspect, and now MacGyver and Penny must flee Bulgaria together.